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H-Glu-OtBu

Short Description:

Name: H-Glu-OtBu
Chemical Name: (S)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid
CAS Number: 45120-30-7
Molecular Formula: C9H17NO4
Molecular Weight: 203.236
Catalog: Biochemical Amino acids and their derivatives Glutamic acid derivative


Product Detail

Product Tags

Names and Identifiers

Name: H-Glu-OtBu
Chemical Name: (S)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid
CAS Number: 45120-30-7
Molecular Formula: C9H17NO4
Molecular Weight: 203.236
Catalog: Biochemical Amino acids and their derivatives Glutamic acid derivative

Other Names

L-Glutamic acid, 1-(1,1-dimethylethyl) ester
L-Glutamic acid α-tert·butyl ester
(4S)-4-Amino-5-[(2-methyl-2-propanyl)oxy]-5-oxopentanoic acid
(4S)-4-Amino-5-tert-butoxy-5-oxopentanoic acid (non-preferred name)
H-Glu-OtBu

Specification

Assay: above 98%
D-isomer: less than 0.3%
Water content: less than 0.5%
Single impurity: less than 0.5%

Usage

H-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2


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