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(S)-1-Boc-3-hydroxypiperidine

Short Description:

image4

CAS: 143900-44-1

MF: C10H19NO3

MW: 201.26


Product Detail

Product Tags

Product Categories

ChiralReagents;Piperidines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Anticancer

Synonyms

(S)-1-Boc-3-Hydroxypiperidine

(S)-1-N-BOC-3-HYDROXY-PIPERIDINE

(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

(S)-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE

(S)-1-BOC-3-PIPERIDINOL

(S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE HYDROCHLORIDE

(S)-N-BOC-3-HYDROXY PIPERIDINE

(S)-TERT BUTYL-3-HYDROXYPIPERIDINE-1-CARBOXYLATE

(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine

S-1-Boc-3-hydroxypiperidine

(3S)-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

(S)-3,5-DifluoroMandelic acid

(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate

(S)-tert-Butyl-3-hydroxypiperidine-1-carboxylate tert- butyl

(3S)-3-hydroxy piperidine-1-carboxylate tert-butyl

(S)-3-hydroxypiperidine-1-carboxylate

(3S)-3-Hydroxypiperidine, N-BOC protected

(S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine

Chemical Properties

Melting point: 34-40 °C

Boiling point: 292.3±33.0 °C(Predicted)

Density: 1.107±0.06 g/cm3(Predicted)

Fp: 110 °C

storage temp: Keep in dark place,Sealed in dry,Room Temperature

solubility: Soluble in methanol.

Pka: 14.74±0.20(Predicted)

Form: Powder or Crystalline Powder

Color: White to tan

optical activity: [α]22/D +10.0°, c = 1 in chloroform

InChIKey: UIJXHKXIOCDSEB-QMMMGPOBSA-N

Hazard identification

1 Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity – single exposure, Category 3

2 GHS label elements, including precautionary statements

Pictogram(s)  image5
Signal word Warning
Hazard statement(s) H315 Causes skin irritation

H319 Causes serious eye irritation

H335 May cause respiratory irritation

Precautionary statement(s)
Prevention P264 Wash ... thoroughly after handling.

P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P271 Use only outdoors or in a well-ventilated area.

Response P302+P352 IF ON SKIN: Wash with plenty of water/...

P321 Specific treatment (see ... on this label).

P332+P317 If skin irritation occurs: Get medical help.

P362+P364 Take off contaminated clothing and wash it before reuse.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P319 Get medical help if you feel unwell.

Storage P403+P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

3 Other hazards which do not result in classification

no data available

Product Specification

Appearance/colour White to off-white solid
It could be agglomerate after storing long times
Identity(IR) Corresponds
Assay(HPLC w/w) 97.0%-103.0%
Chemical purity (GC area) ﹦ 99.0%
Impurity purity (GC w/w) 3-Hydroxypiperidine ﹦ 0.1%
3-Hydroxypyridine ﹦ 0.20% Not Detected
1-Boc-3-piperidone ﹦ 0.10% Not Detected
1-Boc-4-hydroxypiperidine ﹦ 0.10% Not Detected
1.96RRT ﹦ 0.2% Not Detected
Any Unspecified impurity ﹦ 0.08% 0.01%
Chiral purity(HPLC area) ﹦ 99.5%
Methanol(GC) ﹦ 50ppm
Ethanol(GC) ﹦ 50ppm
DCM(GC) ﹦ 500ppm
Water (KF vol w/w) ﹦ 0.5%

Our advantages

1: Our factory realized the big commercialized manufacturing since year 2012, Yearly sales amount reached more than 20tons.
2 It has been the qualified supplier for patent drug company of Ibrutinib.
3 Product quality is super: Assay: 97.0%-103.0%
Chemical purity (GC area): ﹦ 99.0%
Any Unspecified impurity﹤ ﹦ 0.08%
Chiral purity(HPLC area): ﹥ ﹦ 99.5%
4 It is made by Chemical Resolution method.
5 All of the testing methods are validated.
6 One dedicated workshop for making it.


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