ChiralReagents;Piperidines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Anticancer
(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(3S)-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
(S)-tert-Butyl-3-hydroxypiperidine-1-carboxylate tert- butyl
(3S)-3-hydroxy piperidine-1-carboxylate tert-butyl
(3S)-3-Hydroxypiperidine, N-BOC protected
Melting point: 34-40 °C
Boiling point: 292.3±33.0 °C(Predicted)
Density: 1.107±0.06 g/cm3(Predicted)
Fp: 110 °C
storage temp: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in methanol.
Form: Powder or Crystalline Powder
Color: White to tan
optical activity: [α]22/D +10.0°, c = 1 in chloroform
1 Classification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity – single exposure, Category 3
2 GHS label elements, including precautionary statements
|Hazard statement(s)||H315 Causes skin irritation
H319 Causes serious eye irritation
H335 May cause respiratory irritation
|Prevention||P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
|Response||P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label).
P332+P317 If skin irritation occurs: Get medical help.
P362+P364 Take off contaminated clothing and wash it before reuse.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P319 Get medical help if you feel unwell.
|Storage||P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
|Disposal||P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.|
3 Other hazards which do not result in classification
no data available
|Appearance/colour||White to off-white solid
It could be agglomerate after storing long times
|Chemical purity (GC area)||﹥ ﹦ 99.0%|
|Impurity purity (GC w/w)||3-Hydroxypiperidine﹤ ﹦ 0.1%|
|3-Hydroxypyridine﹤ ﹦ 0.20%||Not Detected|
|1-Boc-3-piperidone﹤ ﹦ 0.10%||Not Detected|
|1-Boc-4-hydroxypiperidine﹤ ﹦ 0.10%||Not Detected|
|1.96RRT﹤ ﹦ 0.2%||Not Detected|
|Any Unspecified impurity﹤ ﹦ 0.08%||0.01%|
|Chiral purity(HPLC area)||﹥ ﹦ 99.5%|
|Methanol(GC)||﹤ ﹦ 50ppm|
|Ethanol(GC)||﹤ ﹦ 50ppm|
|DCM(GC)||﹤ ﹦ 500ppm|
|Water (KF vol w/w)||﹤ ﹦ 0.5%|
1: Our factory realized the big commercialized manufacturing since year 2012, Yearly sales amount reached more than 20tons.
2 It has been the qualified supplier for patent drug company of Ibrutinib.
3 Product quality is super: Assay: 97.0%-103.0%
Chemical purity (GC area): ﹦ 99.0%
Any Unspecified impurity﹤ ﹦ 0.08%
Chiral purity(HPLC area): ﹥ ﹦ 99.5%
4 It is made by Chemical Resolution method.
5 All of the testing methods are validated.
6 One dedicated workshop for making it.