(S)-1-Boc-3-hydroxypiperidine
Short Description:
CAS: 143900-44-1
MF: C10H19NO3
MW: 201.26
Product Categories
ChiralReagents;Piperidines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Anticancer
Synonyms
(S)-1-Boc-3-Hydroxypiperidine
(S)-1-N-BOC-3-HYDROXY-PIPERIDINE
(S)-3-HYDROXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(S)-3-HYDROXY-1-(TERT-BUTOXYCARBONYL)PIPERIDINE
(S)-1-BOC-3-PIPERIDINOL
(S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYPIPERIDINE HYDROCHLORIDE
(S)-N-BOC-3-HYDROXY PIPERIDINE
(S)-TERT BUTYL-3-HYDROXYPIPERIDINE-1-CARBOXYLATE
(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine
S-1-Boc-3-hydroxypiperidine
(3S)-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
(S)-3,5-DifluoroMandelic acid
(S)-tert-Butyl 3-hydroxypiperidine-1-carboxylate
(S)-tert-Butyl-3-hydroxypiperidine-1-carboxylate tert- butyl
(3S)-3-hydroxy piperidine-1-carboxylate tert-butyl
(S)-3-hydroxypiperidine-1-carboxylate
(3S)-3-Hydroxypiperidine, N-BOC protected
(S)-N-tert-Butoxycarbonyl-3-hydroxypiperidine
Chemical Properties
Melting point: 34-40 °C
Boiling point: 292.3±33.0 °C(Predicted)
Density: 1.107±0.06 g/cm3(Predicted)
Fp: 110 °C
storage temp: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in methanol.
Pka: 14.74±0.20(Predicted)
Form: Powder or Crystalline Powder
Color: White to tan
optical activity: [α]22/D +10.0°, c = 1 in chloroform
InChIKey: UIJXHKXIOCDSEB-QMMMGPOBSA-N
Hazard identification
1 Classification of the substance or mixture
Skin irritation, Category 2
Eye irritation, Category 2
Specific target organ toxicity – single exposure, Category 3
2 GHS label elements, including precautionary statements
| Pictogram(s) |  |
| Signal word | Warning |
| Hazard statement(s) | H315 Causes skin irritation
H319 Causes serious eye irritation H335 May cause respiratory irritation |
| Precautionary statement(s) | |
| Prevention | P264 Wash ... thoroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
| Response | P302+P352 IF ON SKIN: Wash with plenty of water/...
P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. |
| Storage | P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
3 Other hazards which do not result in classification
no data available
Product Specification
| Appearance/colour | White to off-white solid It could be agglomerate after storing long times |
| Identity(IR) | Corresponds |
| Assay(HPLC w/w) | 97.0%-103.0% |
| Chemical purity (GC area) | ﹥ ﹦ 99.0% |
| Impurity purity (GC w/w) | 3-Hydroxypiperidine﹤ ﹦ 0.1% |
| 3-Hydroxypyridine﹤ ﹦ 0.20% | Not Detected |
| 1-Boc-3-piperidone﹤ ﹦ 0.10% | Not Detected |
| 1-Boc-4-hydroxypiperidine﹤ ﹦ 0.10% | Not Detected |
| 1.96RRT﹤ ﹦ 0.2% | Not Detected |
| Any Unspecified impurity﹤ ﹦ 0.08% | 0.01% |
| Chiral purity(HPLC area) | ﹥ ﹦ 99.5% |
| Methanol(GC) | ﹤ ﹦ 50ppm |
| Ethanol(GC) | ﹤ ﹦ 50ppm |
| DCM(GC) | ﹤ ﹦ 500ppm |
| Water (KF vol w/w) | ﹤ ﹦ 0.5% |
Our advantages
1: Our factory realized the big commercialized manufacturing since year 2012, Yearly sales amount reached more than 20tons.
2 It has been the qualified supplier for patent drug company of Ibrutinib.
3 Product quality is super: Assay: 97.0%-103.0%
Chemical purity (GC area): ﹦ 99.0%
Any Unspecified impurity﹤ ﹦ 0.08%
Chiral purity(HPLC area): ﹥ ﹦ 99.5%
4 It is made by Chemical Resolution method.
5 All of the testing methods are validated.
6 One dedicated workshop for making it.
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